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To protect your Hyper-V Host,  we recommend that you install the antivirus software within the Host and also within virtual machine.

It also, may be necessary to configure the real-time scanning component within the antivirus software to exclude files and entire folders :

Configure the real-time scanning component within your antivirus software to exclude the following directories and files:

• Default virtual machine configuration directory (C:\ProgramData\Microsoft\Windows\Hyper-V)
•  Custom virtual machine configuration directories Default virtual hard disk drive directory (C:\Users\Public\Documents\Hyper-V\Virtual Hard Disks)
• Custom virtual hard disk drive directories Snapshot directories Vmms.exe
• (Note: May need to be configured as process exclusions within the antivirus software)
•  Vmwp.exe (Note: May need to be configured as process exclusions within the antivirus software)

Additionally, when you use Live Migration together with Cluster Shared Volumes on Windows Server 2008 R2, exclude the CSV path “C:\Clusterstorage” and all its subdirectories

Also exclude the root directory that contain your Virtual machines and configuration files

Also exclude the following files extensions :

VHD, VSV, ISO, AVHD, VFD, and XML,